Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action-Reference-Cited by-同舟云学术

Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action

Published:2020-01-01 Issue:1 Volume:12 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Austin Mark¹²,Burschowsky Daniel³,Chan Denice T.Y.¹,Jenkinson Lesley¹,Haynes Stuart¹,Diamandakis Agata¹,Seewooruthun Chitra³,Addyman Alexandra¹,Fiedler Sebastian¹,Ryman Stephanie¹,Whitehouse Jessica¹,Slater Louise H.¹,Hadjinicolaou Andreas V.⁴,Gileadi Uzi⁴,Gowans Ellen¹,Shibata Yoko¹,Barnard Michelle¹,Kaserer Teresa⁵,Sharma Pooja¹,Luheshi Nadia M.⁶,Wilkinson Robert W.⁶,Vaughan Tristan J.²,Holt Sarah V.¹,Cerundolo Vincenzo⁴,Carr Mark D.³,Groves Maria A. T.¹²

Affiliation:

1. Cancer Research UK AstraZeneca Antibody Alliance Laboratory, Cambridge, UK

2. Antibody Discovery & Protein Engineering, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK

3. Leicester Institute of Structural and Chemical Biology and the Department of Molecular and Cell Biology, University of Leicester, Leicester, UK

4. MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK

5. Cancer Research UK, Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK

6. Early Oncology Discovery, Oncology R&D, AstraZeneca, Cambridge, UK

Funder

CRUK Centre Network Structural Biology Accelerator Award

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2020.1801230

Reference61 articles.

1. The immune system and cancer evasion strategies: therapeutic concepts

2. Immune suppressive mechanisms in the tumor microenvironment

3. Immunosuppressive Strategies that are Mediated by Tumor Cells

4. Modulation of cancer-specific immune responses by amino acid degrading enzymes

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