Structure Based Prediction of Asparagine Deamidation Propensity in Monoclonal Antibodies
Author:
Affiliation:
1. Large Molecule Analytical Development, Pharmaceutical Development and Manufacturing Sciences, Janssen R&D, LLC, Malvern, PA, USA
Funder
Janssen Research and Development
Publisher
Informa UK Limited
Subject
Immunology,Immunology and Allergy
Link
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2018.1478646
Reference23 articles.
1. Assessment of chemical modifications of sites in the CDRs of recombinant antibodies
2. In Vivo Deamidation Characterization of Monoclonal Antibody by LC/MS/MS
3. Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain
4. Identification of multiple sources of charge heterogeneity in a recombinant antibody
5. Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics
Cited by 61 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. The Accurate Prediction of Antibody Deamidations by Combining High-Throughput Automated Peptide Mapping and Protein Language Model-Based Deep Learning;Antibodies;2024-09-10
2. Titer and charge-based heterogeneity multiattribute monitoring of mAbs in cell culture harvest using 2D ProA CEX MS;Talanta;2024-08
3. The Plant Proteases-A Group of Potential Pharmacological, Biotechnological, and Industrially Important Enzymes;The Chemistry inside Spices & Herbs: Research and Development;2024-07-04
4. Stability of Protein Pharmaceuticals: Recent Advances;Pharmaceutical Research;2024-06-27
5. LC–MS Characterization and Stability Assessment Elucidate Correlation Between Charge Variant Composition and Degradation of Monoclonal Antibody Therapeutics;The AAPS Journal;2024-04-03
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3