Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents-Reference-Cited by-同舟云学术

Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents

Published:2018-08-18 Issue:6 Volume:10 Page:876-889
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Jiang Xiling¹,Chen Xi¹,Carpenter Thomas J.¹,Wang Jun¹,Zhou Rebecca²,Davis Hugh M.¹,Heald Donald L.¹,Wang Weirong¹

Affiliation:

1. Biologics Development Sciences, Janssen Biotherapeutics, Janssen Research & Development, LLC, Spring House, PA, USA

2. Biology Department, Swarthmore College, Swarthmore, PA, USA

Funder

Janssen Research & Development, LLC

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2018.1480299

Reference58 articles.

1. Recent Advances in Cancer Therapy: An Overview

2. Ebola vaccine R&D: Filling the knowledge gaps

3. Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML

4. Redirection of T-cell effector functions for cancer therapy: bispecific antibodies and chimeric antigen receptors

5. Bispecific antibodies and CARs: generalized immunotherapeutics harnessing T cell redirection

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