Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes
Author:
Affiliation:
1. Attribute Sciences, Process Development, Amgen Inc, Thousand Oaks, CA, USA
2. Department of Therapeutics Discovery, Amgen Research, Amgen Inc, Thousand Oaks, CA, USA
Publisher
Informa UK Limited
Subject
Immunology,Immunology and Allergy
Link
https://www.tandfonline.com/doi/pdf/10.1080/19420862.2021.1887629
Reference48 articles.
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3. Identification of multiple sources of charge heterogeneity in a recombinant antibody
4. Characterization of the Acidic Species of a Monoclonal Antibody Using Weak Cation Exchange Chromatography and LC-MS
5. Ultrasensitive Characterization of Charge Heterogeneity of Therapeutic Monoclonal Antibodies Using Strong Cation Exchange Chromatography Coupled to Native Mass Spectrometry
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