Comprehensive characterisation of the heterogeneity of adalimumab via charge variant analysis hyphenated on-line to native high resolution Orbitrap mass spectrometry-Reference-Cited by-同舟云学术

Comprehensive characterisation of the heterogeneity of adalimumab via charge variant analysis hyphenated on-line to native high resolution Orbitrap mass spectrometry

Published:2018-11-11 Issue:1 Volume:11 Page:116-128
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Füssl Florian¹,Trappe Anne¹²^ORCID,Cook Ken³,Scheffler Kai⁴^ORCID,Fitzgerald Oliver⁵⁶,Bones Jonathan¹⁷^ORCID

Affiliation:

1. Characterisation and Comparability Lab, NIBRT – The National Institute for Bioprocessing Research and Training, Co, Dublin, Ireland

2. School of Biotechnology, Dublin City University, Dublin 9, Ireland

3. Thermo Fisher Scientific, Hemel Hempstead, UK

4. Thermo Fisher Scientific, Germering, Germany

5. St. Vincent’s University Hospital, Dublin 4, Ireland

6. Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland

7. School of Chemical and Bioprocess Engineering, University College Dublin, Dublin 4, Ireland

Funder

Science Foundation Ireland

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

http://www.tandfonline.com/doi/pdf/10.1080/19420862.2018.1531664

Reference51 articles.

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3. Main Quality Attributes of Monoclonal Antibodies and Effect of Cell Culture Components

4. Charge heterogeneity: Basic antibody charge variants with increased binding to Fc receptors

5. Charge variants in IgG1

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