Summary of a workshop on preclinical and translational safety assessment of CD3 bispecifics-Reference-Cited by-同舟云学术

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Summary of a workshop on preclinical and translational safety assessment of CD3 bispecifics

Published:2020-01-01 Issue:1 Volume:17 Page:67-85
ISSN:1547-691X
Container-title:Journal of Immunotoxicology
language:en
Short-container-title:Journal of Immunotoxicology

Author:

Kamperschroer Cris¹,Shenton Jacintha²,Lebrec Hervé³,Leighton John K.⁴,Moore Paul A.⁵,Thomas Oliver⁶

Affiliation:

1. Pfizer Worldwide Research and Development, Groton, CT, USA

2. Nonclinical Safety, Janssen R&D, Spring House, PA, USA

3. Translational Safety, Amgen Research, South San Francisco, CA, USA

4. U. S. Food and Drug Administration, Silver Spring, MD, USA

5. MacroGenics, Rockville, MD, USA

6. Translational Safety, Amgen Research, Munich, Germany

Publisher

Informa UK Limited

Subject

Toxicology,Immunology

Link

https://www.tandfonline.com/doi/pdf/10.1080/1547691X.2020.1729902

Reference67 articles.

1. A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®

2. The making of bispecific antibodies

3. Immune regulation by glucocorticoids

4. A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: Preclinical activity and safety in nonhuman primates

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1. Progresses of T-cell-engaging bispecific antibodies in treatment of solid tumors;International Immunopharmacology;2024-09

2. Immune‐related adverse events of antibody‐based biological medicines in cancer therapy;Journal of Cellular and Molecular Medicine;2024-07

3. Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey;Regulatory Toxicology and Pharmacology;2024-06

4. Optimizing Clinical Translation of Bispecific T‐cell Engagers through Context Unification with a Quantitative Systems Pharmacology Model;Clinical Pharmacology & Therapeutics;2024-05-15

5. Nonclinical Investigation of Cytokine Mitigation Strategies for T-cell–Engaging Bispecifics in the Cynomolgus Macaque;Journal of Immunotherapy;2024-04-02

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