Effect of Omega-3 Fatty Acids on the Lipid Profile of Patients Taking Clozapine

Author:

Caniato Riccardo N.1,Alvarenga Marlies E.2,Angel Garcia-Alcaraz Miguel1

Affiliation:

1. Institute of Mental Health Services, Townsville Health District, 100 Angus Smith Drive, Douglas, Townsville, Queensland, 4810, Australia

2. Department of General Practice, Monash University, Melbourne, Australia

Abstract

Objective: This study aimed to assess the lipid-lowering properties of omega-3 fatty acids (also known as n-3 polyunsaturated fatty acids) in a group of patients taking clozapine. Method: Twenty-eight persons suffering from schizophrenia or schizoaffective disorder and currently taking clozapine participated in an open-label single-arm trial. Participants received supplements of 10 g of fish oil (containing 1.8 g of eicosopentaenoic acid and 1.2 g of docosahexaenoic acid) for a period of 28 days. Plasma lipids were measured on days 0 and 28. Results: This study demonstrated high rates of lipid abnormalities in the participants. Participants taking omega-3 fatty acids demonstrated a statistically significant reduction in mean serum triglyceride levels of 22%. There was an associated increase in total cholesterol (6.6%) and low-density lipoprotein cholesterol (22%). Common side-effects included fishy burps or breath, but no serious side-effects or interactions where observed. Conclusion: Omega-3 fatty acids may be of value in patients taking clozapine and who have elevated serum triglyceride levels. Limitations of the study, practical implications and directions for future research are discussed.

Publisher

SAGE Publications

Subject

Psychiatry and Mental health,General Medicine

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