Cyanthiwigin A-D, Novel Cytotoxic Diterpenes From The Sponge Epipolasis Reiswigi

Author:

Green D.,Goldberg I.,Stein Z.,Ilan M.,Kashman Y.

Publisher

Informa UK Limited

Subject

Molecular Medicine

Reference15 articles.

1. Reiswigins A and B, novel antiviral diterpenes from a deepwater sponge

2. Isoreiswigin, a New Diterpene from a Marine Sponge

3. Extraction Of The Freeze Dried Sponge (18g) With Ch2Cl2Gave A Brown Gum (650mg) From Which Compounds1–4(50,33,6 And 18mg, Respectively) Were Isolated Following Silica Gel Chromatography

4. Cyanthiowigin A(1): C20H30O (M/Z 286 Ei And Cims); Mp 84–85°; [α]D + 7° (C=0.5, Ch2Cl2); V Max (Kbr) 2961, 2922, 1703, 1596, 1449 And 1378 Cm−1; δh (C6D6) See Table 1; Cosy (H To H): 2/18,4; 5/4, 10ax,Eq; 8eq/8ax, 7ax,Eq, Me17; 10eq/10ax, 5, 11eq,Ax; 11ax/11eq, Me15, 10eq,Ax; 14ax/14eq, Me15, Me16; 14eq/14ax, Me16; Noe (H To H (%)); 2/Me20 (1.0); 4/10ax (2.0), Me 17 (1), 2(1.0); 8eq/7ax (1.5); 11ax/5, 14ax (3.5); 14eq/13(9.5), 7eq(2.5); Me 15/13; Me 16/14eq (3.0), 8ax(6.0), 7eq(3.0), 10ax, 4(4.0); Me 17/2(2.0), 4(6.5), 8eq(2.0), 8ax(4.0); 18/10eq(3.0), Me 19 And Me 20

5. The Numbering Of The C-Atoms Of1–4Is According To Cyanthane6

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