1. Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA;
2. South Dakota State University, Brookings, SD, USA;
3. Ironwood Pharmaceuticals, Cambridge, MA, USA;
4. Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA;
5. Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA