Evaluation of eye irritation potential of experimental cosmetic formulations containing glycolic acid, salicylic acid and ethanol using the Bovine Corneal Opacity and Permeability Assay

Author:

Labib R.1,Cantrell K.2,Costin G.-E.2,Milac A. L.3,Raabe H.2,Gettings S.1

Affiliation:

1. Avon Global Research and Development, Suffern, NY, USA

2. Institute for In Vitro Sciences, Inc. (IIVS), Gaithersburg, MD, USA

3. Institute of Biochemistry of the Romanian Academy, Bucharest, Romania

Publisher

Informa UK Limited

Reference45 articles.

1. Survey of ocular irritation predictive capacity using Chorioallantoic Membrane Vascular Assay (CAMVA) and Bovine Corneal Opacity and Permeability (BCOP) test historical data for 319 personal care products over fourteen years

2. OECD. Test No. 437: Bovine Corneal Opacity and Permeability test method for identifying i) Chemicals inducing serious eye damage and ii) Chemicals not requiring classification for eye irritation or serious eye damage; 2023. Available from: https://www.oecd-ilibrary.org/docserver/9789264203846-en.pdf?expires=1717159293&id=id&accname=guest&checksum=7F088AEE446C2816B5E20C8C1E4F04B6. Note: OECD TG 437 was updated in 2023 but no major changes have been made which would affect the assay conduct or interpretations included in this manuscript.

3. ECHA. Guidance on the application of the CLP criteria. Guidance to Regulation (EC) No 1272/2008 on classification labeling and packaging (CLP) of substances and mixtures version 5.0; 2017. Available from: https://echa.europa.eu/documents/10162/23036412/clp_en.pdf/58b5dc6d-ac2a-4910-9702-e9e1f5051cc5

4. NIH. Newly approved ocular safety methods reduce animal testing; 2008.

5. US EPA. Use of an alternate testing framework for classification of eye irritation potential of EPA pesticide products; 2015: 1–39.

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