Design and development of novel focal adhesion kinase (FAK) inhibitors using Monte Carlo method with index of ideality of correlation to validate QSAR

Author:

Kumar P.1ORCID,Kumar A.2,Sindhu J.3

Affiliation:

1. Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, India

2. Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India

3. K. M. Govt. College, Narwana, Haryana, India

Publisher

Informa UK Limited

Subject

Drug Discovery,Molecular Medicine,General Medicine,Bioengineering

Reference46 articles.

1. R.O. Hynes, Integrins: Bidirectional, allosteric signaling machines, Cell 110 (2002), pp. 673–687.

2. The matrix reorganized: extracellular matrix remodeling and integrin signaling

3. Integrin signalling during tumour progression

4. P.J. Reddig and R.L. Juliano, Clinging to life: Cell to matrix adhesion and cell survival, Cancer Metastasis Rev. 24 (2005), pp. 425–439.

5. S.T. Lim, D. Mikolon, D.G. Stupack, and D.D. Schlaepfer, FERM control of FAK function: Implications for cancer therapy, Cell Cycle 7 (2008), pp. 2306–2314.

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