Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents

Author:

Guo Yujin12,Chen Beibei2,Guo Jinxiu2,Jiang Pei12,Wang Jianhua23,Sun Wenxue243

Affiliation:

1. Institute of Clinical Pharmacy, Jining First People′s Hospital, Shandong First Medical University, Jining, P.R. China

2. Translational Pharmaceutical Laboratory, Jining First People′s Hospital, Shandong First Medical University, Jining, P.R. China

3. Postdoctoral of Shandong University of Traditional Chinese Medicine, Jinan, P.R. China

4. Chinese Medicine Innovation Institute, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China

Funder

Program for Taishan Scholar Project of Shandong Province

Natural Science Foundation of Shandong Province

Scientific Research Foundation of Shandong Medical Association

Traditional Chinese Medicine Science and Technology Development Plan of Shandong Province

Projects of medical and health technology development program in Shandong province

Key R&D Program of Jining

Doctoral Fund of Jining NO.1 People′s Hospital

Publisher

Informa UK Limited

Reference26 articles.

1. Turning down PI3K/AKT/mTOR signalling pathway by natural products: an in silico multi-target approach

2. Antiangiogenic agents in the management of non-small cell lung cancer

3. Novel Hybrids of Podophyllotoxin and Coumarin Inhibit the Growth and Migration of Human Oral Squamous Carcinoma Cells

4. A Two-drug Model for Etoposide Action against Human Topoisomerase IIα

5. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung;Chang TH;Clin Cancer Res,2002

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