1. Bristol Heart Institute, University Hospitals Bristol NHS Trust, Bristol, UK;
2. Cardiovascular and Thoracic Department, Careggi University Hospital, Florence, Italy; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy;
3. Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK;
4. Department of Medicine, Section of Cardiology, University of Verona, Verona, Italy;
5. Institute of Cardiovascular Science, University College London, London, UK