Malondialdehyde in benign prostate hypertrophy: a useful marker?-Reference-Cited by-同舟云学术

Malondialdehyde in benign prostate hypertrophy: a useful marker?

Published:2003 Issue:2 Volume:12 Page:127-128
ISSN:0962-9351
Container-title:Mediators of Inflammation
language:en
Short-container-title:Mediators of Inflammation

Author:

Merendino Rosaria Alba¹,Salvo Francesco²,Saija Antonella³,Di Pasquale Giuseppe⁴,Tomaino Antonio³,Minciullo Paola Lucia⁵,Fraccica Giuseppe²,Gangemi Sebastiano⁵

Affiliation:

1. Chair of Immunopathology, Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, Italy

2. School and Division of Urology, Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, Italy

3. School of Pharmacy, Department Farmaco-Biologico, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, Italy

4. Department of Internal Medicine, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, Italy

5. School and Division of Allergy and Clinical Immunology, Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, Italy

Abstract

Benign prostate hypertrophy (BPH) is the most common benign tumor in men due to obstruction of the urethra and, finally, uremia. Malondialdehyde (MDA) is a product derived from peroxidation of polyunsaturated fatty acids and related esters. Evaluation of MDA in serum represents a non-invasive biomarker of oxidative stress. Prostate-specific antigen (PSA) is a sensitive marker for prostatic hypertrophy and cancer. We analyzed MDA serum levels to evaluate the oxidative stress in BPH. To this end, 22 BPH patients and 22 healthy donors were enrolled. Data show an increase of MDA level in BPH patients and a positive correlation between PSA and MDA levels. In conclusion, we describe a previously unknown relationship between PSA and MDA as an index of inflammation and oxidative stress in BPH.

Funder

University of Messina Medical School

Publisher

Hindawi Limited

Subject

Cell Biology,Immunology

Link

http://downloads.hindawi.com/journals/mi/2003/174859.pdf

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