Development and Validation of a Rapid HPLC Method for the Determination of Methadone and its Main Metabolite EDDP in Biological Fluids, Following SPE
Author:
Affiliation:
1. a Laboratory of Analytical Chemistry, Department of Chemistry , Aristotle University of Thessaloniki , Thessaloniki , Greece
Publisher
Informa UK Limited
Subject
Clinical Biochemistry,Pharmaceutical Science,Biochemistry,Analytical Chemistry
Link
https://www.tandfonline.com/doi/pdf/10.1080/10826070500531433
Reference28 articles.
1. Methadone—metabolism, pharmacokinetics and interactions
2. Methadone concentrations in plasma and their relationship to drug dosage
3. Pharmacokinetic profiles of methadone enantiomers and its major metabolite in serum, saliva and urine of treated patients
4. Rapid determination of methadone and its major metabolite in biological fluids by gas–liquid chromatography with thermionic detection for maintenance treatment of opiate addicts
5. Determination of methadone in urine using ion trap GC/MS in positive ion chemical ionization mode
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2. Comparison of the solid phase and liquid-liquid extraction methods for methadone determination in human serum and whole blood samples using gas chromatography/mass spectrometry;Archives of Industrial Hygiene and Toxicology;2017-12-20
3. Direct Analysis of Methadone in Exhaled Breath Condensate by Capillary Zone Electrophoresis;Current Pharmaceutical Analysis;2016-03-06
4. Extraction and Analysis of Methadone in Exhaled Breath Condensate Using a Validated LC-UV Method;Journal of Pharmacy & Pharmaceutical Sciences;2015-06-05
5. In-line solid-phase extraction–capillary electrophoresis coupled with mass spectrometry for determination of drugs of abuse in human urine;Analytical and Bioanalytical Chemistry;2012-02-29
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