Optimization by Factorial Design of a Capillary Electrophoresis Method for the Chiral Resolution and Determination of Zopiclone and Its Synthesis Precursor
Author:
Affiliation:
1. a Department of Physical and Analytical Chemistry , University of Oviedo , Oviedo, Spain
2. b Asturpharma, S.A., Silvota , Llanera, Asturias, Spain
Publisher
Informa UK Limited
Subject
Clinical Biochemistry,Pharmaceutical Science,Biochemistry,Analytical Chemistry
Link
https://www.tandfonline.com/doi/pdf/10.1080/10826070903245672
Reference28 articles.
1. Masaomi , M. Shigenori , O. 2002 , US patent number 6348485 .
2. Zopiclone, a cyclopyrrolone hypnotic: Review of properties
3. Stereoselective distribution and stereoconversion of zopiclone enantiomers in plasma and brain tissues in rats
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2. Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC: Method development and validation;Journal of Pharmaceutical and Biomedical Analysis;2020-10
3. First derivative spectrofluorimetric determination of zopiclone and its degradation product, 2-amino-5-chloropyridine, in pharmaceutical formulations with preliminary tool in biological fluids for clinical evidence of zopiclone intake;Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy;2017-06
4. Quantitative determination of zopiclone and its impurity by four different spectrophotometric methods;Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy;2015-02
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