Quality of life outcomes in APOLLO, the phase 3 trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis

Author:

Obici Laura1,Berk John L.2ORCID,González-Duarte Alejandra3,Coelho Teresa4,Gillmore Julian5,Schmidt Hartmut H.-J.6,Schilling Matthias7,Yamashita Taro8,Labeyrie Céline9,Brannagan Thomas H.10,Ajroud-Driss Senda11,Gorevic Peter12,Kristen Arnt V.13ORCID,Franklin Jaclyn14,Chen Jihong14,Sweetser Marianne T.14,Wang Jing Jing14,Adams David9

Affiliation:

1. Amyloidosis Research and Treatment Centre, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;

2. Amyloidosis Center, Boston Medical Center, Boston, MA, USA;

3. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico;

4. Hospital de Santo António, Centro Hospitalar do Porto, Porto, Portugal;

5. Division of Medicine, National Amyloidosis Centre, University College London, London, UK;

6. Medical Clinic for Gastroenterology and Hepatology, University of Münster, Münster, Germany;

7. Department of Neurology, Institute of Translational Neurology, University Hospital Münster, Münster, Germany;

8. Department of Neurology, Kumamoto University, Kumamoto, Japan;

9. Assistance Publique–Hôpitaux de Paris (APHP), French National Reference Center for Familial Amyloidotic Polyneuropathy, Centre Hospitalier Universitaire Bicêtre, Universite Paris-Sud, INSERM Unite, Paris, France;

10. Department of Neurology, Columbia University Medical Center, New York, NY, USA;

11. Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA;

12. Department of Medicine, Mount Sinai Medical Center, New York, NY, USA;

13. Department of Cardiology, University of Heidelberg, Heidelberg, Germany;

14. Alnylam Pharmaceuticals, Cambridge, MA, USA

Publisher

Informa UK Limited

Subject

Internal Medicine

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