Tafamidis polyneuropathy amelioration requires modest increases in transthyretin stability even though increases in plasma native TTR and decreases in non-native TTR do not predict response

Author:

Monteiro Cecília1ORCID,Mesgarzadeh Jaleh S.1,Anselmo João2,Fernandes Joana2,Novais Marta2,Rodrigues Carla2,Powers David L.3,Powers Evan T.1ORCID,Coelho Teresa24,Kelly Jeffery W.15ORCID

Affiliation:

1. Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA

2. Unidade Corino de Andrade, Centro Hospitalar do Porto, Largo do Prof. Abel Salazar, Porto, Portugal

3. Department of Mathematics, Clarkson University, Potsdam, NY, USA

4. Department of Neurophysiology, Centro Hospitalar do Porto, Largo do Prof. Abel Salazar, Porto, Portugal

5. The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA

Funder

American Heart Association

Ellen Browning Scripps Foundation

NIH

Publisher

Informa UK Limited

Subject

Internal Medicine

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