1. 4) FDA Warns of Rare Acetaminophen Risk. 2013 Aug 1; Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are the two most serious skin reactions linked in rare cases to acetaminophen. They usually require hospitalization and can cause death [http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm363010.htm (accessed 2013-11-16)].