Ultrasound markers informative of efficient non-pharmacological correction of hypofibrinolysis at preconception period in patients with recurrent pregnancy loss-Reference-Cited by-同舟云学术

Ultrasound markers informative of efficient non-pharmacological correction of hypofibrinolysis at preconception period in patients with recurrent pregnancy loss

Published:2021-07-01 Issue:2 Volume:6 Page:31-40
ISSN:2542-0941
Container-title:Fundamental and Clinical Medicine
language:
Short-container-title:Fundamentalʹnaâ i kliničeskaâ medicina

Author:

Lebedeva E. I.¹^ORCID,Yavorskaya S. D.¹^ORCID,Momot A. P.²^ORCID,Fadeeva N. I.¹^ORCID

Affiliation:

1. Altai State Medical University

2. National Research Center for Hematology

Abstract

Aim. To find reliable ultrasound markers of efficient non-pharmacological correction of hypofibrinolysis at preconception period in patients with recurrent pregnancy loss.Materials and Methods. We conducted a single-center, prospective, non-randomized study in patients with recurrent pregnancy loss and hypofibrinolysis (n = 120), who received intermittent pneumatic compression during preconception care. During the pregnancy, we performed a comprehensive 3D ultrasound examination of the endometrium and corpus luteum in the VOCAL mode. Then, we compared patients with (n = 97) and without (n = 23) favorable outcome. Predictive power of the ultrasound parameters was evaluated by a calculation of the area under the receiver operating characteristic (ROC) curve (AUC) and ROC curve comparison.Results. Vascularization flow index of endometrial perfusion (AUC = 0.566) and corpus luteum (AUC = 0.639) was identified as a potential marker of efficient intermittent pneumatic compression at preconception period.Conclusions. Adequate perfusion of endometrium and corpus luteum, reflected by vascularization flow index, may indirectly indicate successful trophoblast invasion and minimize the risk of recurrent pregnancy loss.

Publisher

Kemerovo State Medical University

Reference19 articles.

1. Yakut S, Toru HS, Çetin Z, Özel D, Şimşek M, Mendilcioğlu İ, Lüleci G. Chromosome abnormalities identified in 457 spontaneous abortions and their histopathological findings. Turk Patoloji Derg. 2015;31(2):111-118. https://doi.org/10.5146/tjpath.2015.01303

2. Sidel'nikova VM. Podgotovka i vedenie beremennosti u zhenshchin s privychnym nevynashivaniem : metodicheskie posobiya i klinicheskie protokoly. 3nd ed. Мoscow: Medpress-inform Publ; 2013. (In Russ.).

3. Ye Y, Vattai A, Zhang X, Zhu J, Thaler CJ, Mahner S, Jeschke U, von Schönfeldt V. Role of Plasminogen Activator Inhibitor Type 1 in Pathologies of Female Reproductive Diseases. Int J Mol Sci. 2017;18(8):1651. https://doi.org/10.3390/ijms18081651

4. Momot AP Physiological pregnancy as a model of incomplete thrombosis. Obstetrics and gynaecology of St. Petersburg. 2017;(2):44-52. (In Russ.).

5. Momot A.P., Tomilina O.P., Molchanova I.V., Shipulina V.G., Tsyvkina L.P., Serdyuk G.V., Borisova O.G, Semenova N.A. Znachenie terapevticheskoy korrektsii narusheniy gemostaza i fibrinoliza dlya iskhodov ekstrakorporal'nogo oplodotvoreniya i nalichiya rannikh reproduktivnykh poter'. Gemorragicheskie diatezy, trombozy, trombofilii. 2014;(1). (In Russ.).