HLA-G in asthma and its potential as an effective therapeutic agent
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Published:2023-01-01
Issue:1
Volume:51
Page:22-29
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ISSN:0301-0546
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Container-title:Allergologia et Immunopathologia
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language:
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Short-container-title:Allergol Immunopathol
Author:
Li Jinyan,Hao Yuqiu,Li Wei,Lv Xuejiao,Gao Peng
Abstract
Objective: Asthma is a heterogeneous disease. Severity of asthma and sensitivity to medications vary across asthma subtypes. Human leukocyte antigen (HLA)-G has a wide range of functions in normal and pathological physiology. Due to its powerful immune function, HLA-G participates in the pathogenesis of different asthma phenotypes by regulating the activity and function of various immune cells. The mechanism of HLA-G in asthma is not fully clear, and there is no consensus on its mechanism in asthma. Further studies are needed to explore the role of HLA-G in different phenotypes of human asthma.
Methods: Observational study.
Results: HLA-G is an important immunomodulatory factor in asthma. Studies have found different levels of HLA-G in patients with different asthma subtypes and healthy controls, but other studies have come to the opposite conclusion.
Conclusion: We speculate that further study on the mechanism of HLA-G in asthma pheno-types may explain some of the contradictions in current studies. Findings should provide information regarding the potential of HLA-G as a novel target for asthma diagnosis and treatment.
Publisher
Codon Publications
Subject
General Medicine,Immunology and Allergy,Immunology,Pulmonary and Respiratory Medicine
Cited by
3 articles.
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