The lncRNA PVT1/miR-423-5p axis is positively correlated with the severity of bronchial asthma
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Published:2022-01-01
Issue:1
Volume:50
Page:108-115
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ISSN:0301-0546
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Container-title:Allergologia et Immunopathologia
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language:
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Short-container-title:aei
Author:
Qiu Ju,Zhang Kai,Liu Jing,Cao Dianfeng,Gao Ping,Zhang Baoling,Zhao Na,Wang Ruofang,Shi Xinsheng
Abstract
Bronchial asthma (BA) is a serious problem affecting the quality of life of patients. Long non-coding RNAs (lncRNAs) are involved in BA. This study set out to investigate expressions of PVT1/miR-423-5p in the serum of BA patients and its clinical value on BA diagnosis and evaluation. This study included the same number (N = 100) of patients with BA at remission (BA-R), BA at exacerbation (BA-E), and healthy controls. PVT1 level was increased in BA-R and BA-E patients, and PVT1 level was higher in BA-E patients than BA-R patients. miR-141-3p targeted PVT1. miR-423-5p was downregulated in the serum of BA patients and was negatively correlated with PVT1. Area under ROC curve of PVT1/miR-423-5p axis on BA-R patients was 0.837 with sensitivity 0.74, specificity 0.84, while that of BA-E was 0.974 with sensitivity 0.87 and specificity 0.95. PVT1/miR-423-5p axis was negatively correlated with FEV1/FVC, FEV1% pred, and IL-10, and positively correlated with IgE, TNF-α, and IL-6. PVT1 and PVT1/miR-423-5p axis were associated with increased severity while miR-423-5p axis was negatively associated with BA severity. In conclusion, increased levels of PVT1/miR-423-5p had higher diagnostic efficiency on BA patients, especially patients with acute exacerbation.
Publisher
Codon Publications
Subject
General Medicine,Immunology and Allergy,Immunology,Pulmonary and Respiratory Medicine
Cited by
1 articles.
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