Abstract
While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics.
Funder
Flagship InterOmics
Italian Ministero dell'Istruzione, Università e Ricerca
Consiglio Nazionale delle Ricerche: Flagship Project Epigen, Medicina Personalizzata and Aging Program
Flagship InterOmics project
Publisher
Cold Spring Harbor Laboratory
Cited by
62 articles.
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