Author:
Antanaviciute Agne,Baquero-Perez Belinda,Watson Christopher M.,Harrison Sally M.,Lascelles Carolina,Crinnion Laura,Markham Alexander F.,Bonthron David T.,Whitehouse Adrian,Carr Ian M.
Abstract
Recent methods for transcriptome-wide N6-methyladenosine (m6A) profiling have facilitated investigations into the RNA methylome and established m6A as a dynamic modification that has critical regulatory roles in gene expression and may play a role in human disease. However, bioinformatics resources available for the analysis of m6A sequencing data are still limited. Here, we describe m6aViewer—a cross-platform application for analysis and visualization of m6A peaks from sequencing data. m6aViewer implements a novel m6A peak-calling algorithm that identifies high-confidence methylated residues with more precision than previously described approaches. The application enables data analysis through a graphical user interface, and thus, in contrast to other currently available tools, does not require the user to be skilled in computer programming. m6aViewer and test data can be downloaded here: http://dna2.leeds.ac.uk/m6a.
Funder
Sir Jules Thorn Charitable Trust
Medical Research Council
Biotechnology and Biological Sciences Research Council
Publisher
Cold Spring Harbor Laboratory
Cited by
32 articles.
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