The need for smart bimetallic nanoparticles in the battle against pathogenic multi-drug resistant bacteria: a brief communication

Abstract

AbstractThe expanding threat presented by developing pathogenic multidrug-resistant (MDR) bacteria calls for an urgent need for research, particularly given the growing concern for global public health. Bimetallic nanoparticles (NPs) have the potential to be utilized for a broad variety of pharmacological and biological applications because to their outstanding antibacterial activity at low concentrations and continuous phase stability. This is especially true when it comes to preventing MDR pathogenic bacteria from invading. Several biological synthetic methods for producing bimetallic NPs and the range of analytical methods (used to characterize them) are covered in this brief communication paper. Additionally, I tried to highlight the literature review on the antimicrobial capabilities of several synthesized bimetallic NPs. The final section of this brief communication discussed the structure and mechanism of action of the synthesized bimetallic NPs against pathogenic bacteria. Electrostatic interaction, damage to cell membranes, change of enzymes and proteins, oxidative stress and the production of reactive oxygen species (ROS), binding to proteins that disturbs the electron transport chain and disturbs homeostasis, signal transduction suppression, and genotoxicity are some possible associations with the phenomenon being studied.