Comparative gene expression profiling reveals key changes in expression levels of cephalosporin C biosynthesis and transport genes between low and high-producing strains of Acremonium chrysogenum

Author:

Dumina M. V.,Zhgun A. A.,Novak M. I.,Domratcheva A. G.,Petukhov D. V.,Dzhavakhiya V. V.,Eldarov M. A.,Bartoshevitch Iu. E.

Publisher

Springer Science and Business Media LLC

Subject

Applied Microbiology and Biotechnology,General Medicine,Physiology,Biotechnology

Reference29 articles.

1. Bartoshevich Y, Novak M, Domratcheva A, Skryabin K (2009) Method of cephalosporin C biosynthesis by using new Acremonium chrysogenum strain, RNCM NO F-4081D. No 2426793, Priority 10.05.2011

2. Brakhage AA (1998) Molecular regulation of β-Lactam biosynthesis in filamentous fungi. Microbiol Mol Biol Rev 62:547–585

3. Demain AL, Elander RP (1999) The beta-lactam antibiotics: past, present, and future. Antonie Van Leeuwenhoek 75:5–19

4. Díez B, Velasco J, Marcos AT, Rodríguez M, De La Fuente JL, Barredo JL (2000) The gene encoding gamma-actin from the cephalosporin producer Acremonium chrysogenum. Appl Microbiol Biotechnol 54:786–791

5. Dumina M, Zhgun A, Domracheva A, Novak M, El’darov M (2012) Chromosomal polymorphism of Acremonium chrysogenum strains producing cephalosporin C. J Genet 48:778–784. doi: 10.1134/S1022795412050067

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