Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study
Author:
Funder
North Carolina State University
Oak Ridge National Laboratory
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology
Link
https://link.springer.com/content/pdf/10.1007/s40268-021-00353-4.pdf
Reference56 articles.
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2. Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik MJ. Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology. 1998;88(4):1071–5.
3. Mazoit JX, Le Guen R, Beloeil H, Benhamou D. Binding of long-lasting local anesthetics to lipid emulsions. Anesthesiology. 2009;110(2):380–6. https://doi.org/10.1097/ALN.0b013e318194b252.
4. Litonius E, Lokajova J, Yohannes G, Neuvonen PJ, Holopainen JM, Rosenberg PH, Wiedmer SK. In vitro and in vivo entrapment of bupivacaine by lipid dispersions. J Chromatogr A. 2012;1254:125–31. https://doi.org/10.1016/j.chroma.2012.07.013.
5. French D, Smollin C, Ruan W, Wong A, Drasner K, Wu AH. Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies. Clin Toxicol (Phila). 2011;49(9):801–9. https://doi.org/10.3109/15563650.2011.617308.
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