When to Consider Risk-Reducing Mastectomy in BRCA1/BRCA2 Mutation Carriers with Advanced Stage Ovarian Cancer: a Case Study Illustrating the Genetic Counseling Challenges

Author:

Speight BeverleyORCID,Tischkowitz Marc

Funder

University of Cambridge

Publisher

Wiley

Subject

Genetics(clinical)

Reference26 articles.

1. Alsop, K., Fereday, S., Meldrum, C., deFazio, A., Emmanuel, C., George, J., et al. (2012). BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: A report from the Australian ovarian cancer study group. Journal of Clinical Oncology, 30(21), 2654–2663. doi: 10.1200/JCO.2011.39.8545 .

2. du Bois, A., Reuss, A., Pujade-Lauraine, E., Harter, P., Ray-Coquard, I., & Pfisterer, J. (2009). Role of surgical outcome as prognostic factor in advanced epithelial ovarian cancer: a combined exploratory analysis of 3 prospectively randomized phase 3 multicenter trials: by the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d'Investigateurs Nationaux Pour les Etudes des Cancers de l'Ovaire (GINECO). Cancer, 115(6), 1234–1244. doi: 10.1002/cncr.24149 .

3. Bolton, K. L., Chenevix-Trench, G., Goh, C., Sadetzki, S., Ramus, S. J., Karlan, B. Y., et al. (2012). Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA, 307(4), 382–390. doi: 10.1001/jama.2012.20 .

4. Bookman, M. A., Brady, M. F., McGuire, W. P., Harper, P. G., Alberts, D. S., Friedlander, M., et al. (2009). Evaluation of new platinum-based treatment regimens in advanced-stage ovarian cancer: A phase III trial of the gynecologic cancer intergroup. Journal of Clinical Oncology, 27(9), 1419–1425. doi: 10.1200/JCO.2008.19.1684 .

5. Candido-dos-Reis, F. J., Song, H., Goode, E. L., Cunningham, J. M., Fridley, B. L., Larson, M. C., et al., Australian Ovarian Cancer Study, G. (2015). Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer. Clinical Cancer Research, 21(3), 652–657. doi: 10.1158/1078-0432.CCR-14-2497 .

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