Mechanisms of the Effect of Simulated Microgravity on the Cytotoxicity of NK Cells Following the DNA Methylation of NKG2D and the Expression of DAP10
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Published:2021-01-07
Issue:1
Volume:33
Page:
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ISSN:0938-0108
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Container-title:Microgravity Science and Technology
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language:en
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Short-container-title:Microgravity Sci. Technol.
Author:
Shao Dongyan,Ye Linjie,Zhu Bobo,Li Qi,Yang Hui,Shi Junling,Huang Qingsheng,Zhao Wen
Funder
National Natural Science Foundation of China National Key Research and Development Program of China Shaanxi Provincial Key R&D Program China Postdoctoral Science Foundation Shaanxi Provincial Natural Science Foundation
Publisher
Springer Science and Business Media LLC
Subject
Applied Mathematics,General Physics and Astronomy,General Engineering,Modeling and Simulation
Reference35 articles.
1. Baba, Y., Watanabe, M., Baba, H.: A review of the alterations in DNA methylation in esophageal squamous cell carcinoma. Surg. Today. 43(12), 1355–1364 (2013) 2. Bigley, A.B., Agha, N.H., Baker, F.L., Spielmann, G., Kunz, H.E., Mylabathula, P.L., Rooney, B., Laughlin, M.S., Mehta, S.K., Pierson, D.L., Crucian, B.E., Simpson, R.J.: NK-cell function is impaired during long-duration spaceflight. J. Appl. Physiol. 126(4), 842–853 (2019) 3. Brown, R., Klaus, D., Todd, P.: Effects of space flight, clinorotation, and centrifugation on the substrate utilization efficiency of E. coli. Microgravity Sci. Technol. 13(4), 24–29 (2002) 4. Burgess, S.J., Marusina, A.I., Pathmanathan, I., Borrego, F., Coligan, J.E.: IL-21 down-regulates NKG2D/DAP10 expression on human NK and CD8+ T cells. J. Immunol. 176(3), 1490–1497 (2006) 5. Crucian, B.E., Alexander, C., Simpson, R.J., Satish, M., Gailen, M., Smith, S.M., Zwart, S.R., Martina, H., Sergey, P., Alexandra, W.: Immune system Dysregulation during spaceflight: potential countermeasures for deep space exploration missions. Front. Immunol. 9, 1437 (2018)
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