Intelligent Medicine on the Regulation Effect of Weekend Catch-Up Sleep on the Relationship Between Hypertension and All-Cause Mortality

Abstract

AbstractThe current studies did not take into consideration the significant differences in sleep duration between weekdays and weekends, and the evidence on weekend catch-up sleep and the risk of cardiovascular/metabolic-related diseases was limited. This study was aimed to explore whether weekend catch-up sleep could modify the association between hypertension and all-cause mortality. This cohort study extracted the data of 5344 participants aged > 18 years in NHANES database. Demographic and clinical variables were included, and univariable and multivariable Proportional Hazards Model regression models were utilized to screen the potential confounding factors. The regulation role of mean weekend catch-up sleep on the association between hypertension and all-cause mortality was explored via the interactive product terms including mean weekend catch-up sleep, hypertension and mean weekend catch-up sleep × hypertension. In total, there were 3157 participants had hypertension. The mean follow-up time was 24.45 ± 1.51 months, and 5235 (98.57%) people were alive at the end of the follow-up. The mean weekend catch-up sleep was 0.71 h in alive people and 0.60 h in people with hypertension. After adjusting for age, gender, race, income, body mass index (BMI), depression, respiratory disease, and diabetes, hypertension was associated with an increased risk of all-cause mortality [hazard ratio (HR) = 2.17, 95% confidence interval (CI) 1.19–3.96]. The interaction between hypertension and mean weekend catch-up sleep was statistically significant in the adjusted model (P = 0.048). When we examined the HR for different mean weekend catch-up sleep groups, we observed that in people with mean weekend catch-up sleep ≤ 1 h, the HR of all-cause mortality associated with hypertension was 3.06 (95% CI 1.44–6.47) after adjusting for age, gender, race, income, BMI, depression, respiratory disease, and diabetes. Mean weekend catch-up sleep modified the association between hypertension and all-cause mortality, which suggested that weekend catch-up sleep might be important for people with hypertension. The findings might provide evidence in the management of sleep and hypertension for intelligent medical information system.