Enantioselective Total Syntheses of (−)-Cochlearol B and (+)-Ganocin A

Abstract

AbstractHerein, we describe the first total synthesis of (±)-cochlearol B and the enantioselective total syntheses of (−)-cochlearol and (+)-ganocin A. The key steps include Corey-Bakshi-Shibata reduction, oxidative phenolic cyclization, intramolecular [2+2] photocycloaddition, and intramolecular radical cyclization-benzylic oxidative cyclization, enabling efficient access to 4/5/6/6/6 and 5/5/6/6/6-fused pentacyclic frameworks of these natural products.