Advantages and Disadvantages of PROTACs
Author:
Publisher
Springer Nature Singapore
Link
https://link.springer.com/content/pdf/10.1007/978-981-97-5077-1_4
Reference52 articles.
1. Arthur R, Valle-Argos B, Steele AJ, Packham G (2020) Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors. Explor Target Antitumor Ther 1(3):131–152. https://doi.org/10.37349/etat.2020.00009
2. Authier S, Vargas HM, Curtis MJ, Holbrook M, Pugsley MK (2013) Safety pharmacology investigations in toxicology studies: An industry survey. J Pharmacol Toxicol Methods 68(1):44–51. https://doi.org/10.1016/j.vascn.2013.05.002
3. Békés M, Langley DR, Crews CM (2022) PROTAC targeted protein degraders: the past is prologue. Nat Rev Drug Discov 21(3):181–200. https://doi.org/10.1038/s41573-021-00371-6
4. Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, Mulholland KE, Routly N, Buckley DL, Gustafson JL, Zinn N, Grandi P, Shimamura S, Bergamini G, Faelth-Savitski M, Bantscheff M, Cox C, Gordon DA, Willard RR et al (2015) Catalytic in vivo protein knockdown by small-molecule PROTACs. Nat Chem Biol 11(8):611–617. https://doi.org/10.1038/nchembio.1858
5. Bricelj A, Steinebach C, Kuchta R, Gütschow M, Sosič I (2021) E3 ligase ligands in successful PROTACs: an overview of syntheses and linker attachment points [review]. Front Chem 9. https://doi.org/10.3389/fchem.2021.707317
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