Building with DNA: From Curiosity-Driven Research to Practice

Author:

Zhang Fei

Abstract

AbstractThe origins of DNA nanotechnology can be traced back to 1982, when Dr. Ned Seeman proposed assembling branched junctions as 3D lattices to facilitate protein crystallization. Over the past four decades, this concept has evolved into a multidisciplinary research field with vast potential for applications. In this mini review, we present a brief introduction of selected topics in nucleic acid nanotechnology, focusing on scaling up DNA assembly, achieving higher resolutions, and transferring to RNA structural design. We discusses the advantages and challenges of each topic, aiming to shed light on the enormous potential of nucleic acid nanotechnology.

Publisher

Springer Nature Singapore

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