LAG-3 Inhibitors for the Treatment of Lung Cancer

Author:

Sankpal Kaustubhi,Morparia Saurabh,Suvarna Vasanti,Murahari ManikantaORCID

Publisher

Springer Nature Singapore

Reference67 articles.

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2. Anderson AC, Joller N, Kuchroo VK (2016) Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation. Immunity 44(5):989–1004. https://doi.org/10.1016/j.immuni.2016.05.001

3. Ascierto PA, Bono P, Bhatia S, Melero I, Nyakas MS, Svane I-M, Larkin J, Gomez-Roca C, Schadendorf D, Dummer R, Marabelle A, Hoeller C, Maurer M, Harbison CT, Mitra P, Suryawanshi S, Thudium K, Muñoz Couselo E (2017) Efficacy of BMS-986016, a monoclonal antibody that targets lymphocyte activation gene-3 (LAG-3), in combination with nivolumab in Pts with melanoma who progressed during prior anti–PD-1/PD-L1 therapy (Mel Prior IO) in all-comer and biomarker-enriched populations. Ann Oncol 28:v611–v612. https://doi.org/10.1093/annonc/mdx440.011

4. Ascione A, Arenaccio C, Mallano A, Flego M, Gellini M, Andreotti M, Fenwick C, Pantaleo G, Vella S, Federico M (2019) Development of a novel human phage display-derived anti-LAG3 ScFv antibody targeting CD8+ T lymphocyte exhaustion. BMC Biotechnol 19(1):67. https://doi.org/10.1186/s12896-019-0559-x

5. Avice M-N, Sarfati M, Triebel F, Delespesse G, Demeure CE (1999) Lymphocyte activation Gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-α and IL-12 production by monocytes and dendritic cells. J Immunol 162(5):2748–2753. https://doi.org/10.4049/jimmunol.162.5.2748

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