Fungal Infections

Author:

Todi Subhash,Chawla Rajesh

Publisher

Springer Singapore

Reference4 articles.

1. Darouiche RO. Candida in the ICU. Clin Chest Med. 2009;30(2):287–93. Although treatment for documented, deep-seated Candida infections in nonneutropenic patients has been studied extensively, guidelines for the management of suspected but undocumented cases of invasive Candida infections in critically ill patients have not been clearly established.

2. Hsueh PR, Graybill JR, et al. Consensus statement on the management of invasive candidiasis in intensive care units in the Asia-Pacific region. Int J Antimicrob Agents. 2009;34(3):205–9. Candida albicans remains the predominant cause of invasive candidiasis in ICUs, followed by Candida tropicalis, Candida glabrata, and Candida parapsilosis. Invasive isolates of Candida spp. remain highly susceptible to fluconazole (>90% susceptible), although among Asia-Pacific countries the susceptibility rate of C. glabrata to fluconazole varies widely from 22% to 72%.

3. Lam SW, Eschenauer GA. Evolving role of early antifungals in the adult intensive care unit. Crit Care Med. 2009;37(5):1580–93. The use of early antifungal therapy should be reserved for patients with a high risk (10–15%) of developing invasive candidiasis (IC). There is no single predictive rule that can adequately forecast IC in critically ill patients. Clinicians should assess patients on a case-by-case basis and determine the need for early antifungal treatment strategies based on frequent evaluations of risk factors and clinical status.

4. Peter GP, Carol AK, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62(4):e1–50. IDSA Comprehesive guidelines for the management of candidiasis.

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