Author:
Guldberg Eva,Diederichsen Søren Zöga,Haugan Ketil Jørgen,Brandes Axel,Graff Claus,Krieger Derk,Olesen Morten Salling,Højberg Søren,Køber Lars,Vejlstrup Niels,Bertelsen Litten,Svendsen Jesper Hastrup
Abstract
AbstractEpicardial adipose tissue (EAT) has endocrine and paracrine functions and has been associated with metabolic and cardiovascular disease. This study aimed to investigate the association between EAT, determined by cardiac magnetic resonance imaging (CMR), and incident atrial fibrillation (AF) following long-term continuous heart rhythm monitoring by implantable loop recorder (ILR). This study is a sub-study of the LOOP study. In total, 203 participants without a history of AF received an ILR and underwent advanced CMR. All participants were at least 70 years of age at inclusion and had at least one of the following conditions: hypertension, diabetes, previous stroke, or heart failure. Volumetric measurements of atrial- and ventricular EAT were derived from CMR and the time to incident AF was subsequently determined. A total of 78 participants (38%) were diagnosed with subclinical AF during a median of 40 (37–42) months of continuous monitoring. In multivariable Cox regression analyses adjusted for age, sex, and various comorbidities, we found EAT indexed to body surface area to be independently associated with the time to AF with hazard ratios (95% confidence intervals) up to 2.93 (1.36–6.34); p = 0.01 when analyzing the risk of new-onset AF episodes lasting ≥ 24 h. Atrial EAT assessed by volumetric measurements on CMR images was significantly associated with the incident AF episodes as detected by ILR.
Funder
Novo Nordisk
Innovationsfonden
The Research Foundation for the Capital Region of Denmark
Hjerteforeningen
Aalborg University Talent Management Program
Arvid Nilssons Fond,Denmark
Skibsreder Per Henriksen, R. og hustrus fond,Denmark
The AFFECT-EU Consortium
Læge Sophus Carl Emil Friis og hustru Olga Doris Friis' Legat
Medtronic
National Hospital
Publisher
Springer Science and Business Media LLC