Author:
Jiang Lu,Stärkel Peter,Fan Jian-Gao,Fouts Derrick Eugene,Bacher Petra,Schnabl Bernd
Abstract
AbstractThe human gut microbiome (bacteria, fungi, viruses, and archaea) is a complex and diverse ecosystem. It plays an important role in human health, but is involved in several intestinal and extraintestinal diseases. Most research to date has focused on the role of bacteria, while studies focusing on fungi (also referred to as “mycobiome” or “fungome”) are still in its infancy. In this review, we focus on the existing literature available about the gut mycobiome with an emphasis on compositional mycobiome changes associated with liver diseases, the impact on pathogenesis of disease, and its potential use as therapeutic targets. We also provide insights into current methodologies of studying mycobiome, and we highlight the interkingdom interactions in the context of disease and how they affect health of the host. Herein, by focusing on the gut mycobiome, this review provides novel insights and directions for liver research.
Funder
Biocodex Microbiota Foundation Grant
National Institute on Alcohol Abuse and Alcoholism
Biomedical Laboratory Research and Development, VA Office of Research and Development
National Institute of Diabetes and Digestive and Kidney Diseases
Fond National de Recherche Scientifique Belgium
Action de Recherche Concertée, Université Catholique de Louvain
Publisher
Springer Science and Business Media LLC
Cited by
24 articles.
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