Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties
Author:
Funder
Japan Agency for Medical Research and Development
Japan Society for the Promotion of Science
Publisher
Springer Science and Business Media LLC
Subject
Gastroenterology
Link
http://link.springer.com/article/10.1007/s00535-018-1437-3/fulltext.html
Reference41 articles.
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2. Okamoto R, Watanabe M. Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease. J Gastroenterol. 2016;51:11–21.
3. Clevers H. The intestinal crypt, a prototype stem cell compartment. Cell. 2013;154:274–84.
4. Muñoz JMN, Stange DE, Schepers AG, et al. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent “+4” cell markers. EMBO J. 2012;31:3079–91.
5. Foulke-Abel J, In J, Yin J, et al. Human enteroids as a model of upper small intestinal ion transport physiology and pathophysiology. Gastroenterology. 2016;150:638–49.
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