A theoretical examination of the effects of gut wall metabolism, hepatic elimination, and enterohepatic recycling on estimates of bioavailability and of hepatic blood flow
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics
Link
http://link.springer.com/content/pdf/10.1007/BF01062719.pdf
Reference5 articles.
1. C. V. Greenway and R. D. Stark. Hepatic vascular beds.Physiol. Rev. 51:23–65 (1971).
2. K. S. Pang and M. Rowland. Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance.J. Pharmacokin. Biopharm. 5:625–654 (1977).
3. M. Rowland. The influence of route of administration on drug availability.J. Pharm. Sci. 62:70–74 (1972).
4. M. Gibaldi, R. N. Boyes, and S. Feldman. Influence of first-pass effect on availability of drugs on oral administration.J. Pharm. Sci. 61:1338–1340 (1971).
5. D. G. Shand, D. M. Kornhauser, and G. R. Wilkinson. Effect of route of administration and blood flow on hepatic drug elimination.J. Pharmacol. Exp. Ther. 195:424–432 (1975).
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