Association between ambulatory blood pressure monitoring patterns with cognitive function and risk of dementia: a systematic review and meta-analysis
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Published:2023-03-30
Issue:4
Volume:35
Page:745-761
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ISSN:1720-8319
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Container-title:Aging Clinical and Experimental Research
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language:en
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Short-container-title:Aging Clin Exp Res
Author:
Gavriilaki Maria,Anyfanti Panagiota,Mastrogiannis Konstantinos,Gavriilaki Eleni,Lazaridis Antonios,Kimiskidis Vasilios,Gkaliagkousi Eugenia
Abstract
Abstract
Background
The objective of this systematic review and meta-analysis is to investigate whether nocturnal blood pressure fall, expressed by dipping patterns according to 24 h ambulatory blood pressure monitoring (ABPM), is associated with abnormal cognitive function (cognitive impairment or dementia).
Methods
We systematically searched PubMed, Embase, and Cochrane databases to identify original articles through December 2022. We included any study with at least ten participants reporting on all-cause dementia or cognitive impairment incidence (primary outcome) or validated cognitive tests (secondary outcome) among ABPM patterns. We assessed risk of bias using Newcastle–Ottawa Quality Assessment Scale. We pooled odds ratios (OR) and standardized mean differences (SMD) using random-effect models for primary and secondary outcome, respectively.
Results
In the qualitative synthesis, 28 studies examining 7595 patients were included. The pooled analysis of 18 studies showed that dippers had a 51% [OR 0.49(0.35–0.69)] lower risk of abnormal cognitive function and a 63% [OR 0.37(0.23–0.61)] lower risk of dementia alone, compared to non-dippers. Reverse dippers presented an up to sixfold higher risk [OR 6.06(3.15–11.64)] of abnormal cognitive function compared to dippers and an almost twofold higher risk [OR 1.81(1.26–2.6)] compared to non-dippers. Reverse dippers performed worse in global function neuropsychological tests compared with both dippers [SMD − 0.66(− 0.93 to − 0.39)] and non-dippers [SMD − 0.35(− 0.53 to − 0.16)].
Conclusion
Dysregulation of the normal circadian BP rhythm, specifically non-dipping and reverse dipping is associated with abnormal cognitive function. Further studies are required to determine potential underlying mechanisms and possible prognostic or therapeutic implications.
Protocol registration
PROSPERO database (ID: CRD42022310384).
Funder
Aristotle University of Thessaloniki
Publisher
Springer Science and Business Media LLC
Subject
Geriatrics and Gerontology,Aging
Cited by
1 articles.
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