Abstract
Abstract
Background
Circulating metabolites (CM) play a pivotal role in our overall health, yet the current evidence concerning the involvement of diverse CM in benign prostatic hyperplasia (BPH) remains limited. Mendelian randomization (MR) offers a promising avenue to explore the potential impact of CM on BPH.
Methods
In a forward MR analysis, a cohort of 249 circulating metabolites was employed as exposures to investigate their potential associations with BPH risk. Conversely, in a reverse MR analysis, BPH was employed as an exposure to assess its effects on CM.
Results
The forward MR analysis discerned a linkage between six metabolites and BPH, with careful consideration to excluding heterogeneity and pleiotropy. Subsequently, the reverse MR analysis unveiled that nine metabolic compounds, mainly comprising phospholipids and triglycerides, potentially exhibit elevated levels in BPH patients.
Conclusion
Bidirectional MR analysis furnishes genetic insight into the interplay between CM and BPH. The prominence of lipids and triglycerides emerges as significant factors intricately linked to BPH risk.
Funder
Guangxi Science and Technology Base and Talent Project
Fundamental Research Ability Improvement Project for Young and Middle aged Teachers in Guangxi Universities
Innovation Project of Guangxi Graduate Education of GXUCM
Administration of Traditional Chinese Medicine of Guangxi Zhuang Autonomous Region Self-funded Scientific Research Project
Health Commission of Guangxi Zhuang Autonomous Region self-funded scientific research project
Natural Science Research Project of Guangxi University of Traditional Chinese Medicine
Publisher
Springer Science and Business Media LLC
Subject
Geriatrics and Gerontology,Aging