Author:
Berton Federico,Costantinides Fulvia,Stacchi Claudio,Corradini Ambra,Di Lenarda Andrea,Di Lenarda Roberto
Abstract
Abstract
Objectives
The aim of this clinical observational study was to assess the efficacy of L-PRF as a hemostatic agent in patients under treatment with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs).
Materials and methods
Patients under oral anticoagulant therapy (VKA or DOACs) who needed a single simple tooth extraction were enrolled. L-PRF plug was positioned inside the alveolus and secured with non-absorbable sutures. Surgical time, pain-VAS, paracetamol intake, intra-operative, post-operative biological complications, and bleeding events have been registered.
Results
A total of 112 patients (59 patients for DOAC and 53 for VKA group) were enrolled. Post-operative bleeding was recorded in nine patients (17%) for VKA group and nine patients (15.3%) for DOACs group. None of the patients needed a medical support for managing of bleeding. Seven days after surgery, no cases of post-extractive complications occurred.
Conclusions
The use of L-PRF resulted in limited mild late post-operative bleedings without the need of medical intervention.
Clinical relevance
The use of L-PRF can be adopted for an uneventful post-operative curse in anticoagulated patients without chasing their therapy for single tooth extraction.
Funder
Università degli Studi di Trieste
Publisher
Springer Science and Business Media LLC
Reference36 articles.
1. Ministero della Salute Italiano (2017) Alleanza italiana per le malattie cardio-cerebrovascolari, Documento di strategia http://www.salute.gov.it/imgs/C_17_pubblicazioni_2606_allegato.pdf. Accessed 15 February 2022.
2. Caliskan M, Tükel HC, Benlidayi ME, Deniz A (2017) Is it necessary to alter anticoagulation therapy for tooth extraction in patients taking direct oral anticoagulants? Med Oral Patol Oral Cir Bucal 22:767–773
3. Lupi SM, Rodriguez Y Baena A (2020) Patients taking direct oral anticoagulants (DOAC) undergoing oral surgery: a review of the literature and a proposal of a peri-operative management protocol. Healthcare (Basel) 8:281. https://doi.org/10.3390/healthcare8030281
4. Costantinides F, Rizzo R, Pascazio L, Maglione M (2016) Managing patients taking novel oral anticoagulants (NOAs) in dentistry: a discussion paper on clinical implications. BMC Oral Health 16:5. https://doi.org/10.1186/s12903-016-0170-7
5. Manfredi M, Dave B, Percudani D, Christoforou J, Karasneh J, Diz Dios P, Glick M, Kumar N, Lockhart PB, Patton LL (2019) World workshop on oral medicine VII: direct anticoagulant agents management for invasive oral procedures: a systematic review and meta-analysis. Oral Dis 25(S 1):157–173. https://doi.org/10.1111/odi.13086
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献