Adaptive Activation of Thyroid Hormone and Energy Expenditure-Reference-Cited by-同舟云学术

Adaptive Activation of Thyroid Hormone and Energy Expenditure

Published:2005-06-08 Issue:3-4 Volume:25 Page:191-208
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Bianco Antonio C.¹,Maia Ana Luiza¹,da Silva Wagner Seixas¹,Christoffolete Marcelo A.¹

Affiliation:

1. Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, HIM Bldg. #643, Massachusetts, Boston, MA, 02115, USA

Abstract

The mechanisms by which thyroid hormone accelerates energy expenditure are poorly understood. In the brown adipose tissue (BAT), activation of thyroid hormone by type 2 iodothyronine deiodinase (D2) has been known to play a role in adaptive energy expenditure during cold exposure in human newborns and other small mammals. Although BAT is not present in significant amounts in normal adult humans, recent studies have found substantial amounts of D2 in skeletal muscle, a metabolically relevant tissue in humans. This article reviews current biological knowledge about D2 and adaptive T3 production and their roles in energy expenditure.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/25/3-4/191/472517/bsr0250191.pdf

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