Experimental Strategies Towards Treating Mitochondrial DNA Disorders-Reference-Cited by-同舟云学术

Experimental Strategies Towards Treating Mitochondrial DNA Disorders

Published:2007-06-13 Issue:1-3 Volume:27 Page:139-150
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Gardner Julie L.¹,Craven Lyndsey¹,Turnbull Douglass M.²,Taylor Robert W.¹

Affiliation:

1. Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

2. Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, UK

Abstract

An extensive range of molecular defects have been identified in the human mitochondrial genome (mtDNA), causing a range of clinical phenotypes characterized by mitochondrial respiratory chain dysfunction. Sadly, given the complexities of mitochondrial genetics, there are no available cures for mtDNA disorders. In this review, we consider experimental, genetic-based strategies that have been or are being explored towards developing treatments, focussing on two specific areas which we are actively pursuing—assessing the benefit of exercise training for patients with mtDNA defects, and the prevention of mtDNA disease transmission.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/27/1-3/139/474450/bsr0270139.pdf

Reference60 articles.

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