Dimethyl Fumarate Prevents HIV-Induced Lysosomal Dysfunction and Cathepsin B Release from Macrophages

Author:

Rosario-Rodríguez Lester J.,Colón Krystal,Borges-Vélez Gabriel,Negrón Karla,Meléndez Loyda M.

Funder

National Institute of General Medical Sciences

National Institute of Mental Health

National Institute on Minority Health and Health Disparities

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,Immunology,Immunology and Allergy,Neuroscience (miscellaneous)

Reference63 articles.

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2. Ancuta P, Kamat A, Kunstman KJ, Kim EY, Autissier P, Wurcel A, Zaman T, Stone D, Mefford M, Morgello S, Singer EJ, Wolinsky SM, Gabuzda D (2008) Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. PLoS One 3:e2516. https://doi.org/10.1371/journal.pone.0002516

3. Anderson AM, Muñoz-Moreno JA, McClernon D, Ellis RJ, Cookson D, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan J, Morgello S, Sacktor N, Simpson DM, Franklin DR, Heaton RK, Grant I, Letendre SL, CHARTER Group (2016) Prevalence and correlates of persistent HIV-1 RNA in cerebrospinal fluid during antiretroviral therapy. J Infect Dis 215:105–113. https://doi.org/10.1093/infdis/jiw505

4. Aquaro S, Scopelliti F, Pollicita M, Perno CF (2008) Oxidative stress and HIV infection: target pathways for novel therapies? Futur HIV Ther 2:327–338. https://doi.org/10.2217/17469600.2.4.327

5. Brennan MS, Matos MF, Li B, Hronowski X, Gao B, Juhasz P, Rhodes KJ, Scannevin RH (2015) Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro. PLoS One 10:e0120254. https://doi.org/10.1371/journal.pone.0120254

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