Canagliflozin Mitigated Cognitive Impairment in Streptozotocin-Induced Sporadic Alzheimer’s Disease in Mice: Role of AMPK/SIRT-1 Signaling Pathway in Modulating Neuroinflammation

Author:

Khamies Sara M.,El-Yamany Mohammed F.,Ibrahim Sherehan M.

Publisher

Springer Science and Business Media LLC

Reference89 articles.

1. Abdel Rasheed NO, Sayed E, N. S., El-Khatib AS (2018) Targeting central β2 receptors ameliorates streptozotocin-induced neuroinflammation via inhibition of glycogen synthase kinase3 pathway in mice. Prog Neuropsychopharmacol Biol Psychiatry 86:65–75. https://doi.org/10.1016/j.pnpbp.2018.05.010

2. Afees OJ, Ayodele BR, Gbenga A, Taiye AS, Yinka OS, Dayo O, Sunday FO, Leviticus A, Esther OO, Igbo EJ (2022) Localised streptozotocin-induced structural and cognitive changes in the hippocampal cornu ammonis 1 (CA-1) neurons and mitigating effects of Zingiber officinale. Phytomed Plus 2(1):101–162. https://doi.org/10.1016/j.phyplu.2021.100162

3. Akhtar A, Dhaliwal J, Saroj P, Uniyal A, Bishnoi M, Sangeeta Pilkhwal Sah (2020) Chromium Picolinate Attenuates Cognitive Deficit in ICV-STZ Rat Paradigm of Sporadic Alzheimer’s-like Dementia via Targeting Neuroinflammatory and IRS-1/PI3K/AKT/GSK-3β Pathway. Inflammopharmacology 28 (2): 385–400. https://doi.org/10.1007/s10787-019-00681-7

4. Akhtar A, Dhaliwal J, Sangeeta Pilkhwal Sah (2021) 7,8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer’s disease by reversing oxidative stress, mitochondrial dysfunction, and insulin resistance. Psychopharmacology 238(7):1991–2009. https://doi.org/10.1007/s00213-021-05826-7

5. Albeely AM, Ryan SD, Perreault ML (2018) Pathogenic feed-Forward mechanisms in Alzheimer’s and Parkinson’s Disease converge on GSK-3. Brain Plast 4(2):151–167. https://doi.org/10.3233/bpl-180078

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