A critical review of the reproductive safety of Leflunomide
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Medicine,Rheumatology
Link
http://link.springer.com/content/pdf/10.1007/s10067-019-04819-4.pdf
Reference24 articles.
1. Gotestam Skorpen C et al (2016) The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis 75(5):795–810
2. Arava (leflunomide) prescribing information. Bridgewater (NJ): Sanofi-Aventis. URL: http://products.sanofi.us/arava/arava.html
3. Holmes LB (2011) Human teratogens: update 2010. Birth Defects Res A Clin Mol Teratol. 91(1):1–7
4. Brent RL (2001) Teratogen update: reproductive risks of leflunomide (Arava); a pyrimidine synthesis inhibitor: counseling women taking leflunomide before or during pregnancy and men taking leflunomide who are contemplating fathering a child. Teratology 63(2):106–112
5. Fukushima R et al (2007) Teratogenicity study of the dihydroorotate-dehydrogenase inhibitor and protein tyrosine kinase inhibitor leflunomide in mice. Reprod Toxicol 24(3-4):310–316
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