Higher infection risk for JAK inhibitors tofacitinib and baricitinib compared to subcutaneous biological DMARDs

Author:

Opdam M. A. A.ORCID,Broeder N.den,van den Bemt B. J. F.,Mulder K.,van de Wiel K. M.,van Ballegooijen H.,van Crevel R.,den Broeder A. A.

Funder

Pfizer Pharmaceuticals

Publisher

Springer Science and Business Media LLC

Reference15 articles.

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2. Listing J, Gerhold K, Zink A (2013) The risk of infections associated with rheumatoid arthritis, with its comorbidity and treatment. Rheumatology (Oxford) 52(1):53–61. https://doi.org/10.1093/rheumatology/kes305

3. Singh JA, Cameron C, Noorbaloochi S, Cullis T, Tucker M, Christensen R, Ghogomu ET, Coyle D, Clifford T, Tugwell P, Wells GA (2015) Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis. Lancet 386(9990):258–265. https://doi.org/10.1016/s0140-6736(14)61704-9

4. Bechman K, Subesinghe S, Norton S, Atzeni F, Galli M, Cope AP, Winthrop KL, Galloway JB (2019) A systematic review and meta-analysis of infection risk with small molecule JAK inhibitors in rheumatoid arthritis. Rheumatology (Oxford) 58(10):1755–1766. https://doi.org/10.1093/rheumatology/kez087

5. Curtis JR, Xie F, Yun H, Bernatsky S, Winthrop KL (2016) Real-world comparative risks of herpes virus infections in tofacitinib and biologic-treated patients with rheumatoid arthritis. Ann Rheum Dis 75(10):1843–1847. https://doi.org/10.1136/annrheumdis-2016-209131

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