The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study

Author:

Hirai Takuya,Ikeda Keigo,Fujishiro Maki,Tsushima Hiroshi,Hayakawa Kunihiro,Suzuki Satoshi,Yamaguchi Ayako,Nozawa Kazuhisa,Morimoto Shinji,Takasaki Yoshinari,Ogawa Hideoki,Takamori Kenji,Tamura Naoto,Sekigawa Iwao

Funder

JSPS (Japan Society for the Promotion of Science)

MEXT (Ministry of Education, Culture, Sports, Science and Technology)

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Rheumatology

Reference25 articles.

1. Hazlewood GS, Barnabe C, Tomlinson G, Marshall D, Devoe D, Bombardier C (2016) Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying antirheumatic drugs for rheumatoid arthritis: abridged Cochrane systematic review and network meta-analysis. BMJ 353:i1777. doi: 10.1136/bmj.i1777

2. Nagashima M, Matsuoka T, Saitoh K, Koyama T, Kikuchi O, Yoshino S (2006) Treatment continuation rate in relation to efficacy and toxicity in long-term therapy with low-dose methotrexate, sulfasalazine, and bucillamine in 1,358 Japanese patients with rheumatoid arthritis. Clin Exp Rheumatol 24(3):260–267

3. Kitahama M, Nakajima A, Inoue E, Taniguchi A, Momohara S, Yamanaka H (2013) Efficacy of adjunct tacrolimus treatment in patients with rheumatoid arthritis with inadequate responses to methotrexate. Mod Rheumatol 23(4):788–793. doi: 10.1007/s10165-012-0745-3

4. de Jong PH, Hazes JM, Barendregt PJ, Huisman M, van Zeben D, van der Lubbe PA, Gerards AH, de Jager MH, de Sonnaville PB, Grillet BA, Luime JJ, Weel AE (2013) Induction therapy with a combination of DMARDs is better than methotrexate monotherapy: first results of the tREACH trial. Ann Rheum Dis 72(1):72–78. doi: 10.1136/annrheumdis-2011-201162

5. Ogasawara M, Tamura N, Kageyama M, Onuma S, Kusaoi M, Toyama S, Sekiya F, Matsudaira R, Nawata M, Tada K, Matsushita M, Kempe K, Amano H, Morimoto S, Yamaji K, Takasaki Y (2012) Single-center, retrospective analysis of efficacy and safety of tacrolimus as a second-line DMARD in combination therapy and the risk factors contributing to adverse events in 115 patients with rheumatoid arthritis. Clin Rheumatol 31(2):251–257. doi: 10.1007/s10067-011-1810-6

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