Pharmacokinetics of a New Neuroprotector — Indenoquinoxalinone Derivative after Intravenous Administration in Rabbits and Rats

Author:

Yanovskaya E. A.,Frelikh G. A.,Lakeev A. P.,Chernysheva G. A.,Smol’yakova V. I.,Kovrizhina A. R.

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference11 articles.

1. Plotnikov MB, Chernysheva GA, Smolyakova VI, Aliev OI, Trofimova ES, Sherstoboev EY, Osipenko AN, Khlebnikov AI, Anfinogenova YJ, Schepetkin IA, Atochin DN. Neuroprotective effects of a novel inhibitor of c-Jun N-terminal Kinase in the rat model of transient focal cerebral ischemia. Cells. 2020;9(8):1860. doi: https://doi.org/10.3390/cells9081860

2. Plotnikov MB, Chernysheva GA, Aliev OI, Smol’iakova VI, Fomina TI, Osipenko AN, Rydchenko VS, Anfinogenova YJ, Khlebnikov AI, Schepetkin IA, Atochin DN. Protective effects of a New C-Jun N-terminal Kinase inhibitor in the model of global cerebral ischemia in rats. Molecules. 2019;24(9):1722. doi: https://doi.org/10.3390/molecules24091722

3. Atochin DN, Schepetkin IA, Khlebnikov AI, Seledtsov VI, Swanson H, Quinn MT, Huang PL. A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice. Neurosci. Lett. 2016;618:45-49. doi: https://doi.org/10.1016/j.neulet.2016.02.033

4. Schepetkin IA, Plotnikov MB, Khlebnikov AI, Plotnikova TM, Quinn MT. Oximes: novel therapeutics with anticancer and anti-inflammatory potential. Biomolecules. 2021;11(6):777. doi: https://doi.org/10.3390/biom11060777

5. Schepetkin IA, Chernysheva GA, Aliev OI, Kirpotina LN, Smol’yakova VI, Osipenko AN, Plotnikov MB, Kovrizhina AR, Khlebnikov AI, Plotnikov EV, Quinn MT. Neuroprotective effects of the lithium salt of a novel JNK inhibitor in an animal model of cerebral ischemia-reperfusion. Biomedicines. 2022;10(9):2119. doi: https://doi.org/10.3390/biomedicines10092119

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